In order to prevent address clashes due to the limited range of the 7-bit addresses, a new 10-bit address scheme has been introduced. This enhancement can be mixed with 7-bit addressing and increases the available address range by about a factor of ten. After the start condition, a leading ‘11110’ introduces the 10-bit addressing scheme. The last two address bits of the first byte concatenated with the eight bits of the second byte form the complete 10-bit address. Devices which only use 7-bit addressing simply ignore messages with the leading ‘11110’. The following picture shows the first two bytes of a transfer with a 10-bit address.

A master transmitter addresses the slave with two address bytes as described above with the RW-Bit=’0′ followed by data bytes from the master. The master receiver transfer is only possible with a Combined Transfer because the second address byte can only be transmitted if the RW-Bit of the first address byte is ‘0’. Hence, the start of a master receiver transfer will be the same as a master transmitter transfer followed by a repeated start condition and the first address byte with RW-Bit=’1′ (switching to slave transmitter mode). Please refer to the following master receiver sequence:
- Start condition
- First address byte, RW-Bit=’0′, ACK from the slave
- Second address byte, ACK from the slave
- Repeated start condition (no stop condition!)
- First address byte again, RW-Bit=’1′, ACK from the slave, slave switches to transmit mode
- Slave transmits data bytes, ACK from master
- After the last data byte, the master sends a NACK
- Stop condition
Please consult the I2C specification for details.