The image below shows a typical I2C transmission. A closer look at the signals discloses small spikes in the signals. These spikes are caused by the cross-channel capacitance Cc. In general, crosstalk should not be a problem as long as the resulting spikes are not too large. Cc itself can be minimized by keeping interconnections as short as possible. Increasing the serial resistors Rs and termination Rp can help to reduce the effects of the cross-channel capacitance Cc.
Crosstalk between SDA and SCL
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